TUhjnbcbe - 2021/5/22 12:05:00
TODAY今日发布CurrHypertensRepDec01,:21(12)今日发布02篇（共计06篇）CurrCardiolRepDec01,:21(12)今日发布01篇（共计11篇）EURJCARDIOTHORACDec01,:56(6)今日发布01篇（共计32篇）JAHADec03,:8(23)今日发布07篇（共计50篇）CircCardiovascIntervDec01,:12(12)今日发布01篇（共计07篇）CardiovascDrugsTherEarlyRecent,Nov26,今日发布01篇JIntervCardElectrophysiolEarlyRecent,Nov26,今日发布01篇ATVBDec01,:39(12)今日发布20篇IntJCardiovascImagingEarlyRecent,Nov27,今日发布01篇StrokeEarlyRecent,Nov27,今日发布06篇RECOMMEND推荐阅读01未定源性及其他亚型缺血性脑卒中微栓子信号的检测Strokeresearch-articleEikoHiguchi,SonoToi,etc.1小时前等64用户推荐阅读本文BackgroundandPurposeEmbolicstrokeofundeterminedsource(ESUS)hasbeenproposedtocausethromboembolicinfarctionfromunknownbutpotentialembolicsources.However,anembolusremainsundetectedinESUS.Thegoalofthisstudywastocharacterizetheprevalenceandriskfactorsofmicroembolicsignals(MESs)inESUS.来源不明的栓塞性卒中（ESUS）被认为是由未知但潜在的栓塞来源引起的血栓栓塞性脑梗死。然而，在ESUS中仍没有发现栓子。本研究的目的是探讨微栓子信号（MESs）在体外超声中的患病率及危险因素。MethodsWeexaminedpatientswithacuteischemicstrokeintheinternalcarotidarteryterritoryortransientischemicattackwithin14daysofsymptomonsetandwhowereadmittedtoourhospitalbetweenAprilandMarch.MESsweremonitoredinthemiddlecerebralarteryontranscranialDopplerfor60minutes.WeexaminedtheprevalenceandnumberofMESinESUSandotherstrokesubtypes,suchascardioembolism,largearteryatherosclerosis,cerebralsmallvesseldisease,andtransientischemicattack.ThepresentstudywasregisteredinUniversityHospitalMedicalInformationNetworkClinicalTrialsRegistry(UMIN).我们检查了名在症状出现后14天内颈内动脉区域急性缺血性卒中或短暂性缺血性发作的患者，这些患者在年4月至年3月期间入院。用经颅多普勒超声监测大脑中动脉病变60分钟。我们检测了ESUS和其他中风亚型中MES的患病率和数量，如心脏栓塞、大动脉粥样硬化、脑小血管疾病和短暂性脑缺血发作。医院医学信息网临床试验注册处（UMIN）注册。ResultsMESsweredetectedin33(31%)ofpatients.ESUSshowedthehighestproportion(12/24[50%]),followedbylargearteryatherosclerosis(8/20[40%]),cardioembolism(6/18[33%]),transientischemicattack(4/24[17%]),andcerebralsmallvesseldisease(3/21[14%]).Univariateanalysisshowedthathighersystolicbloodpressure,bodymassindex,hemoglobinA1c,andESUSweresignificantlyassociatedwithMES.Inmultiplelogisticregressionanalysis,ESUSremainedsignificantlyassociatedwithMESafteradjustmentfordescribedcovariatesfromunivariateanalysis(oddsratio,2.86[95%CI,1.01–8.08]).例患者中有33例（31%）发现脏乱。ESUS所占比例最高（12/24[50%]），其次是大动脉粥样硬化（8/20[40%]）、心脏栓塞（6/18[33%]）、短暂性脑缺血发作（4/24[17%]）和脑小血管疾病（3/21[14%]）。单因素分析显示，较高的收缩压、体重指数、血红蛋白A1c和ESUS与MES显著相关。在多因素logistic回归分析中，在对单因素分析中描述的协变量进行调整后，esu与MES仍显著相关（优势比，2.86[95%CI，1.01–8.08]）。ConclusionsThisstudydemonstratedsignificantassociationofESUSwithMES,supportingtheembolicnatureofthisstrokesubtype.这项研究证明了ESUS与MES的显著相关性，支持了这种卒中亚型的栓塞性质。扫描